<html> <head> <!-- Global Site Tag (gtag.js) - Google Analytics --> <script async src="https://www.googletagmanager.com/gtag/js?id=UA-106291659-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments)}; gtag('js', new Date()); gtag('config', 'UA-106291659-1'); </script> <title>Publications</title> <STYLE type="text/css"> <!-- BODY { font-family: sans-serif } /* 0000|0000 */ --> </STYLE> </head> <body bgcolor="#FFFFFF" text="#000000" link="#6d3c32" vlink="#6d3c32"> <basefont size=4> <TABLE align=center BORDER="0" CELLPADDING="1" CELLSPACING="0" WIDTH="500" BGCOLOR="#FFFFFF"> <TR> <TD WIDTH="500" BGCOLOR="#f6bfbc" ALIGN="CENTER"><IMG SRC="image/dot.gif" WIDTH="1" HEIGHT="4" BORDER="0"></TD> </TR> <TR> <TD WIDTH="500"> <CENTER><FONT SIZE="3"><A HREF="index_e.html">Top</A> | <a href="research_e.html">Research</a> | <a href="members_e.html">Members</a> | <a href="publications_e.html">Publications</a> | <a href="history_e.html">History</a> |<a href="contact_e.html">Contact/Access</a></FONT> </CENTER></TD> </TR> <TR> <TD WIDTH="500" BGCOLOR="#f6bfbc" ALIGN="CENTER"><IMG SRC="image/dot.gif" WIDTH="1" HEIGHT="4" BORDER="0"></TD> </TR> </TABLE> <br> <table align="center"> <tr><td colspan="7" width="800" height="70" align="center" bgcolor="#FF6699"><font size=6>Publications<br> </font></td></tr> <table align="center"> <tr> <td align="left" width="800"><br><font size=5>Original papers</font></td> </tr> <tr> <td align="left" width="800"> (36) Sakuma, S., Sato, A., Kojima, N., Tao, F. and Arai, F. Force sensor probe using quartz crystal resonator with wide measurement range for mechanical characterization of HepG2 spheroid. Sensor. Actuat. A-Phys., 265, 202-210 (2017). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (35) Sayo, K., Aoki, S. and Kojima, N. Fabrication of bone marrow-like tissue in vitro from dispersed-state bone marrow cells. Regen. Ther., 3, 32-37 (2016). </td> </tr> <tr> <td align="left" width="800"> (34) Kamitori, S., Ozeki, Y. and Kojima, N. -galactoside-mediated tissue organization during islet reconstitution. Regen. Ther., 3, 11-14 (2016). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (35) Motoyama, W., Sayo, K., Mihara, H., Aoki, S. and Kojima, N. Induction of hepatic tissues in multicellular spheroids composed of murine fetal hepatic cells and embedded hydrogel beads. Regen. Ther., 3, 7-10 (2016). </td> </tr> <tr> <td align="left" width="800"> (32) Okada, R., Hara, T., Sato, T., Kojima, N. and Nishina, Y. The mechanism and control of Jagged1 expression in Sertoli cells. Regen. Ther., 3, 75-81 (2016).</td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (31) Yano, Y., Iimura, N., Kojima, N. and Uchiyama, H. Non-neural and cardiac differentiating properties of Tbx6-expressing mouse embryonic stem cells. Regen. Ther., 3, 1-6 (2016). </td> </tr> <tr> <td align="left" width="800"> (30) Hasan, I., Sugawara, S., Fujii, Y., Koide, Y., Terada, D., Iimura, N., Fujiwara, T., Takahashi, K.G., Kojima, N., Rajia, S., Kawsar, S.M.A., Kanaly, R.A., Uchiyama, H., Hosono, M., Ogawa, Y., Fujita, H., Hamako, J., Matsui, T. and Ozeki, Y. MytiLec, a mussel R-type lectin, interacts with surface glycan Gb3 on Burkitt's lymphoma cells to trigger apoptosis through multiple pathways. Mar. Drugs, 13, 7377-7389 (2015). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (29) Kojima, N., Takeuchi, S. and Sakai, Y. Fabrication of microchannel networks in multicellular spheroids. Sensor. Actuat. B-Chem., 198, 249-254 (2014). </td> </tr> <tr> <td align="left" width="800"> (28) Kojima, N., Takeuchi, S. and Sakai, Y. Engineering of Pseudoislets: Effect on Insulin Secretion Activity by Cell Number, Cell Population, and Microchannel Networks. Transplant. Proc., 46, 1161-1165 (2014). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (27) Katsuda, T., Kojima, N., Ochiya, T. and Sakai, Y. Biliary epithelial cells play an essential role in the reconstruction of hepatic tissue with a functional bile ductular network. Tissue Eng., 19, 2402-2411 (2013). </td> </tr> <tr> <td align="left" width="800"> (26) Kojima, N. and Sakai, Y. Control of liver tissue reconstitution in mesenteric leaves: the effect of preculture on mouse hepatic progenitor cells prior to transplantation. J. Robot. Mechatron., 25, 698-704 (2013). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (25) Kojima, N., Takeuchi, S. and Sakai, Y. Rapid aggregation of heterogeneous cells and multiple-sized microspheres in methylcellulose medium. Biomaterials, 33, 4508-4514 (2012). </td> </tr> <tr> <td align="left" width="800"> (24) Nishikawa, M., Yanagawa, N., Kojima, N., Yuri, S., Hauser, P.V., Jo, O.D. and Yanagawa, N. Stepwise renal lineage differentiation of mouse embryonic stem cells tracing in vivo development. Biochem. Biophys. Res. Commun., 417, 897-902, (2012). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (23) Kojima, N., Takeuchi, S. and Sakai, Y. Establishment of self-organization system in rapidly formed multicellular heterospheroids. Biomaterials, 32, 6059-6067 (2011). </td> </tr> <tr> <td align="left" width="800"> (22) Hamon, M., Ozawa, T., Montagne, K., Kojima, N., Ishii, R., Yamaguchi, S., Nagamune, T., Ushida, T. and Sakai, Y. Avidin-biotin-based approach to forming heterotypic cell clusters and cell sheets on a gas-permeable membrane. Biofabrication, 3, 034111 (10 pp) (2011). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (21) Kojima, N., Saito, H., Nishikawa, M., Yuri, S., Jo, O.D., Pam, P.C., Yanagawa, N. and Yanagawa, N. Lithium induces c-Ret expression in mouse inner medullary collecting duct cells. Cell. Signal., 23, 371-379 (2011). </td> </tr> <tr> <td align="left" width="800"> (20) Kojima, N., Miura, K., Matsuo, T., Nakayama, H., Komori, K., Takeuchi, S. and Sakai, Y. Rapid and direct cell-to-cell attachment using avidin-biotin binding system: Large aggregate formation in suspension culture and small tissue element formation having a precise microstructure using optical tweezers. J. Robot. Mechatron., 22, 619-622 (2010). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (19) Chowdhury, MM., Katsuda, T., Montagne, K., Kimura, H., Kojima, N., Akutsu, H., Ochiya, T., Fujii, T. and Sakai, Y. Enhanced effects of secreted soluble factor preserve better pluripotent state of embryonic stem cells culture in a membrane-based compartmentalized micro-bioreactor. Biomed. Microdevices., 12, 1097-1105 (2010). </td> </tr> <tr> <td align="left" width="800"> (18) Komori, K., Takamiya, S., Kojima, N., Kuwazuru, O., Yoshikawa, N., Furukawa, K., Miyamoto, K. and Sakai, Y. Mechanical Characterization of a Cell-loaded Elastin Film Prepared by Use of a Novel Cross-linker, Dode-DSP. Chem. Lett., 38, 878-879 (2009). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (17) Nishikawa, M., Yamamoto, T., Kojima, N., Komori, K., Fujii, T. and Sakai, Y. Stable immobilization of rat hepatocytes as hemispheroids onto collagen-conjugated poly-dimethylsiloxane (PDMS) surfaces: Importance of direct oxygenation through PDMS for both formation and function. Biotechnol. Bioeng., 99, 1472-1481 (2008). </td> </tr> <tr> <td align="left" width="800"> (16) Nishikawa, M., Kojima, N., Komori, K., Yamamoto, T., Fujii, T. and Sakai, Y. Enhanced maintenance and functions of rat hepatocytes induced by combination of on-site oxygenation and coculture with fibroblasts. J. Biotechnol., 133, 253-260 (2008). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (15) Hanada, S., Kojima, N. and Sakai, Y. Soluble factor-dependent in vitro growth and maturation of rat fetal liver cells in a three-dimensional culture system. Tissue Eng., 14, 149-160 (2008). </td> </tr> <tr> <td align="left" width="800"> (14) Naruto, N., Huang, H., Nishikawa, M., Kojima, N., Mizuno, A., Ohta, K. and Sakai, Y. Feasibility of direct oxygenation of primary-cultured rat hepatocytes using polyethylene glycol decorated liposome-encapsulated hemoglobin (LEH). J. Biosci. Bioeng., 104, 343-346 (2007). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (13) Sekine, K., Chen, YR., Kojima, N., Ogata, K., Fukamizu, A. and Miyajima, A. Foxo1 links insulin signaling to C/EBPa and regulates gluconeogenesis during liver development. EMBO J., 26, 3607-3615 (2007). </td> </tr> <tr> <td align="left" width="800"> (12) Huang, H., Oizumi, S., Kojima, N., Niino T. and Sakai, Y. Avidin-biotin binding-based cell seeding and perfusion culture of liver-derived cells in a porous scaffold with a three-dimensional interconnected flow-channel network. Biomaterials, 28, 3815-3823 (2007). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (11) Huang, H., Hanada, S., Kojima, N. and Sakai, Y. Enhanced Functional Maturation of Fetal Porcine Hepatocytes in Three-dimensional Poly-L-lactic Acid Scaffolds: A Culture Condition Suitable for Engineered Liver Tissues in Large-Scale Animal Studies. Cell Transplant., 15, 799-809 (2006). </td> </tr> <tr> <td align="left" width="800"> (10) Kojima, N., Matsuo, T. and Sakai, Y. Rapid hepatic cell attachment onto biodegradable polymer surfaces without toxicity using an avidin-biotin binding system. Biomaterials, 27, 4904-4910 (2006). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (9) Kojima, N., Shiojiri, N. Sakai, Y and Miyajima, A. Expression of neuritin during liver maturation and regeneration. FEBS Lett., 579, 4562-4566, (2005). </td> </tr> <tr> <td align="left" width="800"> (8) Jiang, J., Kojima, N., Guo, L., Naruse, K., Makuuchi, M., Miyajima, A., Yan, W.-Q. and Sakai, Y. Efficacy of engineered liver tissue based on poly-L-lactic acid scaffolds and fetal mouse liver cells cultured with oncostatin M, nicotinamide and dimethyl sulfoxide. Tissue Eng., 10, 1577-1586, (2004). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (7) Jiang, J., Kojima, N., Kinoshita, T., Miyajima, A., Yan, W., Sakai, Y. Cultivation and induction of fetal liver cells in poly-L-lactic acid scaffold. Mater. Sci. Eng. C, 24, 361-363, (2004). </td> </tr> <tr> <td align="left" width="800"> (6) Hanada, S., Kayano, H., Jiang, J., Kojima, N., Miyajima, A., Sakoda, A. and Sakai, Y. Enhanced in vitro maturation of subcultivated fetal human hepatocytes in three dimensional culture using poly-L-lactic acid scaffolds in the presence of oncostatin. Int. J. Artif. Organs., 26, 943-951, (2003). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (5) Sakai, Y., Jiang, J., Kojima, N., Kinoshita, T. and Miyajima, A. Enhanced in vitro maturation of fetal mouse liver cells with oncostatin M, nicotinamide, and dimethyl sulfoxide. Cell Transplant., 11, 435-441, (2002). </td> </tr> <tr> <td align="left" width="800"> (4) Jiang, J., Kojima, N., Kinoshita, T., Miyajima, A., Yan, W. and Sakai, Y. Cultivation of fetal liver cells in a three-dimensional poly-L-lactic acid scaffold in the presence of oncostatin M. Cell Transplant., 11, 403-406, (2002). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (3) Kamiya, A., Kojima, N., Kinoshita, T., Sakai, Y. and Miyaijma, A. Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: induction of tryptophan oxygenase. Hepatology, 35, 1351-1359, (2002). </td> </tr> <tr> <td align="left" width="800"> (2) Kojima, N., Kinoshita, T., Kamiya, A., Nakamura, K., Nakashima, K., Taga, T. and Miyajima, A. Cell density-dependent regulation of hepatic development by a gp130-independent pathway. Biochem. Biophys. Res. Commun., 277, 152-158, (2000). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (1) Takagi, M., Kojima, N. and Yoshida, T. Analysis of the ammonia metabolism of rat primary hepatocytes and a human hepatocyte cell line Huh 7. Cytotechnology, 32, 9-15, (2000). </td> </tr> <tr> <td align="left" width="800"><br><font size=5>Reviews and books</font></td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (5) Tao, F., Mihara, H. and Kojima, N. Generation of hepatic tissue structures using spheroid culture. Methods in Molecular Biology, in press. </td> </tr> <tr> <td align="left" width="800"> (4) Kojima, N., Tao, F., Mihara, H. and Aoki, S. Chapter 8: Methods for Engineering of Multicellular Spheroids to Reconstitute the Liver Tissue. in  Stem Cells and Cancer in Hepatology , etd. by Y.W. Zheng, Elsevier, pp.145-158 (2018). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (3) Kojima, N. In vitro reconstitution of pancreatic islets. Organogenesis, 10, 225-230 (2014). </td> </tr> <tr> <td align="left" width="800"> (2) Sakai, Y., Jiang, J., Hanada, S., Huang, H., Katsuda, T., Kojima, N., Teratani, T. and Ochiya, T. Three-dimensional culture of fetal mouse, rat and porcine hepatocytes. in  Human Fetal Tissue Transplantation , etd. by N. Bhattacharya and P. Stubblefield, Springer-Verlag UK, pp.47-63 (2013). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (1) Sakai, Y., Nishikawa, M., Evenou, F., Hamon, H., Huang, K., Montagne, K.P., Kojima, N., Fujii, T. and Niino, T. Engineering of implantable liver tissues. in  Liver Stem Cells etd. by T. Ochiya, Humana Press, pp.189-216 (2012). </td> </tr> <tr> <td align="left" width="800"><br><font size=5>Reviews and books in Japanese</font></td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (11) \\8Of_ _0}i 00d0\iD}T~n0\O, Organ Biology, 24, 93-96 (2017). </td> </tr> <tr> <td align="left" width="800"> (10) \\8Of_RbWF{ 3.5.4{0uSOtX0!j#PW0_0ؚ_jD}T~n0uRQbS, 0}ހ>yOf[, 'YTŖKN}W, 000>y, 135-141 (2016). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (9) \\8Of_ ؚ|'`W0Wk000000000W 0000 N!kCQ0000000000000 000000000, 197-204, (2015). </td> </tr> <tr> <td align="left" width="800"> (8) 0u-NwN, WK\m}, v\NaN, \\8Of_ ^NJO0ƀRΑn0Qu;SBv0N]ӁhV, ƀ, 70, 473-485 (2015). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (7) \\8Of_ >\e*Q -N\Nal RN^L.0pu.z0}ހƖVk000]D}T~Ssan0pet000S.0u#uxvz, 65, 83-88, (2013). </td> </tr> <tr> <td align="left" width="800"> (6) \\8Of_ zQ fl RN^L.00}ހ TX000000k0P}TW0f0i SY00bSh0]0n0S'`.0u#uxvz, 63, 3-8, (2011). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (5) ] f \\8Of_ q\,g[U -N\im я_l7KQՈ 䅕N+Y RN^L.0uSOQtXn0Bfzzvj0!j#P0X0_0ؚ_jD}T~n0i{.0u#uxvz, 60, 152-159, (2008). </td> </tr> <tr> <td align="left" width="800"> (4) \\8Of_ RN^L. *gRS0}ހ0(uD0_0pu@bvj0D}T~n0Qi{h0]0n06R_. e,gQuoky;Sf[OzOP[;Sf[MOOK%RQ 20}Q000}ހy ilBvn0[Ka N] "Qu;SBvn0[sk0TQ0_0Sf[0bSn0hT }n0t" 0uQulf_} 00000DO'Y* , 102-106 (2008). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (3) \\8Of_ ~g>\ g9j RN^L.00000"0000P}Tk000ؚ[^j00}ހD}T~n0i{.0u#uxvz, 57, 87-89, (2005). </td> </tr> <tr> <td align="left" width="800"> (2) \\8Of_ RN^L. 000N]D}T~n0pu@bvj0y ih0Qu. e,gQuoky;Sf[O, 2, 93-100, (2004). </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (1) \\8Of_ [\{. zvun0RP[_jifh0]0n0_(u. 00000000h00000000, 60, 11-15, (2002). </td> </tr> <tr> <td align="left" width="800"><br><font size=5>Awards</font></td> </tr> <tr> <td align="left" width="800"> (8) Owތ, \\8Of_, _0}i 00d0\iD}T~n0\O, ,{43Ve,gӁhVOX[uir;Sf[Of[SƖO, qgN0qgNy'Yf[, 2016t^11g27e </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (7) g*Qyތ00000 , *j\m^z'Yf[\\8Of_xvz[000\\8Of_, 0u>\eT, g PYz, s^lŖ[, s^lw_ , ;ek_jRn0SO0/eH00ӁhV-bS, ;ek_jRREALIZE PROJECT the AWARD;ek00000, qgN0 n700000000B, 2016t^2g11e </td> </tr> <tr> <td align="left" width="800"> (6) *Qyތ, *j\m^z'Yf[\\8Of_xvz[000\\8Of_, 0u>\eT, g PYz, s^lŖ[, s^lw_ , ӁhV-]f[k0We0D0_0ؚ_jS0000ӁhVn0zv, ;ek_jRREALIZE PROJECT;ek00000qgN'YO, qgN0DMM.make AKIBA, 2015t^10g25e </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (5) Best Paper Award, Kojima, N., Motoyama, W., and Aoki, S., Assembly of the Hybrid Multicellular Spheroids using Epithelial Cells and Hydrogel Beads, 25th IEEE International Symposium on Micro-Nano Mechatronics and Human Science in 2014 (MHS2014), Noyori Conference Hall, Nagoya University, Aichi, November 12 2014. </td> </tr> <tr> <td align="left" width="800"> (4) g*Qyzvhތ, \\8Of_, MEMSh0Ӂ, ,{4VBEANS}TxvzO, CSI0U^5_0000000, 2012t^5g22e </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (3) Young Investigator Award  Silver Prize , Kojima, N., Takeuchi, S., and Sakai, Y., Fabrication of multicellular heterospheroids by a dispenser robot system, International Conference on Biofabrication 2011 in Toyama, Toyama International Conference Center, Toyama, October 8 2011. </td> </tr> <tr> <td align="left" width="800"> (2) *Qyzvhތ, \\8Of_, 0000n0`Th0 g_j0000000, ,{3VBEANS}TxvzO, ^yHY]0MELONDIAB0U000Α, 2011t^5g17e </td> </tr> <tr> <td align="left" bgcolor="#eebbcb" width="800"> (1) g*Qyzvhތ, \\8Of_, 00000ӁhVn0\O0e, ,{2VBEANS}TxvzO, qgN00000000^-N, 2010t^6g16e </td> </tr> </table> <br> <br> <TABLE align=center BORDER="0" CELLPADDING="1" CELLSPACING="0" WIDTH="500" BGCOLOR="#FFFFFF"> <TR> <TD WIDTH="500" BGCOLOR="#f6bfbc" ALIGN="CENTER"><IMG SRC="image/dot.gif" WIDTH="1" HEIGHT="4" BORDER="0"></TD> </TR> <TR> <TD WIDTH="500"> <CENTER><FONT SIZE="3"><A HREF="index_e.html">Top</A> | <a href="research_e.html">Research</a> | <a href="members_e.html">Members</a> | <a href="publications_e.html">Publications</a> | <a href="history_e.html">History</a> |<a href="contact_e.html">Contact/Access</a></FONT> </CENTER></TD> </TR> <TR> <TD WIDTH="500" BGCOLOR="#f6bfbc" ALIGN="CENTER"><IMG SRC="image/dot.gif" WIDTH="1" HEIGHT="4" BORDER="0"></TD> </TR> </TABLE> </body> </html>